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Filtered Search Results
Medchemexpress LLC ER-27319 maleate | 1204480-26-1 | 99.4% | 396.44 | 100 MG
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ER-27319 maleate is an acridone derivative, a potent and selective SYK inhibitor that inhibits the tyrosine phosphorylation of SYK and its activity. It inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM, making it suitable for the study of allergic diseases.
- Inhibits antigen-induced generation of inositol phosphates
- Inhibits release of arachidonic acid
- Inhibits secretion of histamine and tumor necrosis factor α
- Selectively inhibits the tyrosine phosphorylation of SYK
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Medchemexpress LLC U-99194 maleate | 234757-41-6 | 99.2% | 10 MG
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U-99194 maleate is a selective, potent dopamine D3 receptor antagonist with a Ki of 160 nM. It inhibits the activation of the D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. This compound can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors.
- Selective, potent dopamine D3 receptor antagonist
- Inhibits activation of D3 receptor
- Abrogates IPSC-suppressive effect of D3 agonist PD 128907 in rat hippocampal slices
- Significantly suppresses nicotine-induced tremor in mice
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Medchemexpress LLC Asenapine maleate | 85650-56-2 | 99.95% | 401.84 | 10 MG
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Asenapine maleate (Org 5222 maleate) is a brain-penetrant atypical antipsychotic, serving as an antagonist for serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4), and histamine receptors (pKi: 8.2-9.0). This compound is valuable in the research of schizophrenia and bipolar disorder.
- Higher affinity for 5-HT2C, 5-HT2A, 5-HT2B, 5-HT7, 5-HT6, α2B, and D3 receptors compared to D2 receptor affinity.
- Demonstrated anxiolytic-like effects in animal models.
- Used for treating schizophrenia and bipolar I disorder.
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Medchemexpress LLC AZD9496 maleate | ≥95.0% | 2 MG
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AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist. It acts as an orally bioavailable selective oestrogen receptor degrader (SERD).
- Potent and selective ERα antagonist
- Orally bioavailable selective oestrogen receptor degrader (SERD)
- IC50 of 0.28 nM
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Medchemexpress LLC Flupirtine Maleate | 75507-68-5 | 100.0% | 420.39 | 100 MG
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Flupirtine Maleate is an orally active, blood-brain barrier-crossing non-opioid analgesic and neuroprotective agent. It functions as a neuronal potassium channel opener (Kv7 activator), an NMDA receptor antagonist, and a GABA receptor activator. This agent is suitable for research related to focal cerebral ischemia, pain, Alzheimer's disease, or multiple sclerosis.
- Stabilizes blood-brain barrier integrity.
- Reduces oxidative stress and brain leukocyte infiltration.
- Enhances angioneurogenesis.
- Suppresses calcium influx.
- Stabilizes neuronal resting membrane potential.
- Counteracts focal cerebral ischemia.
- Exhibits analgesic and muscle relaxant properties.
- Protects neurons from excitotoxic, ischemic, or cytokine-mediated death.
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Medchemexpress LLC Omigapil maleate | 200189-97-5 | 99.8% | 391.42 | 25 MG
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Omigapil maleate (CGP3466B) is an orally active GAPDH nitrosylation inhibitor that abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. It has potential for Alzheimer's disease research and is also an apoptosis inhibitor. Additionally, it can be used for congenital muscular dystrophy (CMD) research.
- Orally active GAPDH nitrosylation inhibitor.
- Abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice.
- Potential for Alzheimer's disease research.
- Apoptosis inhibitor.
- Can be used for congenital muscular dystrophy (CMD) research.
- Click chemistry reagent with an alkyne group for CuAAc reactions.
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Medchemexpress LLC NB-598 Maleate | 155294-62-5 | 99.4% | 565.74 | 2 MG
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NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE) that suppresses triglyceride biosynthesis through the farnesol pathway. It also functions as a click chemistry reagent, containing an Alkyne group.
- Potent and competitive inhibitor of squalene epoxidase (SE)
- Suppresses triglyceride biosynthesis through the farnesol pathway
- Click chemistry reagent containing an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
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Medchemexpress LLC Enalapril (maleate) | 76095-16-4 | 99.95% | 250 MG
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Enalapril maleate, also known as MK-421 maleate, is the active metabolite of enalapril and functions as an angiotensin-converting enzyme (ACE) inhibitor. Enalapril is a prodrug that is rapidly metabolized in the liver to enalaprilat following oral administration. It is a potent, competitive inhibitor of ACE, which is responsible for converting angiotensin I to angiotensin II, a key regulator of blood pressure. Enalapril may be used to treat essential or renovascular hypertension and symptomatic congestive heart failure. This product is for research use only.
- Harmful if swallowed.
- Causes skin and serious eye irritation.
- May cause respiratory irritation.
- Avoid breathing dust, fume, gas, mist, vapors, or spray.
- Keep container tightly sealed in a cool, well-ventilated area, away from moisture and direct sunlight.
- Wear protective gloves, clothing, eye protection, and face protection.
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Medchemexpress LLC Enalapril (maleate) | 76095-16-4 | 99.99% | 5 G
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Enalapril (MK-421) maleate is an angiotensin-converting enzyme (ACE) inhibitor and the active metabolite of enalapril. This prodrug is rapidly metabolized in the liver to enalaprilat after oral administration. It is a potent, competitive inhibitor of ACE, an enzyme crucial for converting angiotensin I to angiotensin II, which regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS).
- Treats essential or renovascular hypertension
- Treats symptomatic congestive heart failure
- Functions as a potent, competitive ACE inhibitor
- Metabolized to enalaprilat in the liver
- For research use only
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Medchemexpress LLC Enalapril maleate | 76095-16-4 | 100.0% | 1 ML
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Enalapril maleate is an active metabolite of enalapril and a potent angiotensin-converting enzyme (ACE) inhibitor. As a prodrug, it is rapidly metabolized to enalaprilat, which helps regulate blood pressure by targeting the renin-angiotensin-aldosterone system (RAAS). It is used in the treatment of essential or renovascular hypertension and symptomatic congestive heart failure.
- Active metabolite of enalapril
- Angiotensin-converting enzyme (ACE) inhibitor
- Prodrug that converts to enalaprilat
- Potent and competitive ACE inhibitor
- Used to treat hypertension
- Used to treat congestive heart failure
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Medchemexpress LLC Trimebutine maleate | 34140-59-5 | 99.7% | 1 G
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Trimebutine maleate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. It inhibits L-type Ca2+ and large-conductance calcium-activated potassium channels, blocking ion influx and efflux. It also targets Toll-like receptors, suppressing signals and inhibiting LPS-induced IRAK1, ERK1/2, JNK, and NF-κB activation for anti-inflammatory effects. It induces tumor cell apoptosis via AKT/ERK pathway inhibition and prevents excessive smooth muscle contraction, making it useful for gastrointestinal disorder studies.
- Multi-target inhibitor and opioid receptor agonist
- Exhibits antimuscarinic activity
- Blocks calcium influx and potassium ion efflux
- Suppresses Toll-like receptor signals
- Provides anti-inflammatory effects
- Induces tumor cell apoptosis
- Inhibits excessive smooth muscle contraction
- Useful in gastrointestinal disorder research
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Medchemexpress LLC Velnacrine maleate | 118909-22-1 | HY-W011246 | 98.0% | 330.34 | 100 MG
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Velnacrine maleate (HP 029) is an orally active cholinesterase inhibitor that can be used for the research of Alzheimer's disease.
- Orally active
- Cholinesterase inhibitor
- Used for research of Alzheimer's disease
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Medchemexpress LLC AZD9496 maleate | 1639042-28-6 | 99.4% | 50 MG
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AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with an IC50 of 0.28 nM. It functions as an orally bioavailable selective estrogen receptor degrader (SERD), identified as a laboratory chemical.
- Potent and selective estrogen receptor (ERα) antagonist
- Orally bioavailable selective estrogen receptor degrader (SERD)
- Suitable for scientific research
- Used in signaling pathways
- For research use only
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Medchemexpress LLC Ethynodiol diacetate | 297-76-7 | 99.9% | 1 ML
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Ethynodiol diacetate is a click chemistry reagent that contains an Alkyne group. It can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Features and benefits:
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with molecules containing azide groups
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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5000382736 CEFCAPENE PIVOXIL H 100MG
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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